|
MENTAL RETARDATION, AUTOSOMAL DOMINANT 55, WITH SEIZURES
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In summary, our data suggest that NgBR expression is essential to promoting ERα positive breast cancer cell resistance to paclitaxel.
|
29373839 |
2018 |
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found the expression of NgBR is increased in tamoxifen-resistant ERα-positive breast cancer cells.
|
30208932 |
2018 |
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Nogo-B was recently shown to be involved in proliferation, apoptosis and invasiveness of cancer cells, whereas its specific receptor (NgBR) was found to be up-regulated in estrogen receptor-α positive breast cancer.
|
25075030 |
2014 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Nogo-B receptor expression correlates negatively with malignancy grade and ki-67 antigen expression in invasive ductal breast carcinoma.
|
25202063 |
2014 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Our previous work demonstrated that NgBR is highly expressed in breast cancer cells, where it promotes epithelial mesenchymal transition (EMT), an important step in metastasis.
|
26840457 |
2016 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found the expression of NgBR is increased in tamoxifen-resistant ERα-positive breast cancer cells.
|
30208932 |
2018 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In summary, our data suggest that NgBR expression is essential to promoting ERα positive breast cancer cell resistance to paclitaxel.
|
29373839 |
2018 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Nogo-B was recently shown to be involved in proliferation, apoptosis and invasiveness of cancer cells, whereas its specific receptor (NgBR) was found to be up-regulated in estrogen receptor-α positive breast cancer.
|
25075030 |
2014 |
|
Invasive Ductal Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
A previous study demonstrated that NgBR was highly expressed in human breast invasive ductal carcinoma and promoted epithelial-mesenchymal transition in breast tumor cells.
|
29904947 |
2018 |
|
Invasive Ductal Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We examined NgBR expression in 233 patients with invasive ductal breast carcinoma (IDC) and corresponding non-malignant breast tissues (NMBT) on mRNA (real-time polymerase chain reaction) and protein levels (immunohistochemistry; IHC and western-blot analysis).
|
25202063 |
2014 |
|
Invasive Ductal Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Our previous work has shown that NgBR is highly expressed in human breast invasive ductal carcinoma.
|
25173099 |
2015 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Nogo-B receptor expression correlates negatively with malignancy grade and ki-67 antigen expression in invasive ductal breast carcinoma.
|
25202063 |
2014 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Significant NgBR mRNA down-regulation was associated with larger primary tumor size (p=0.039), lymph node involvement (p=0.039) and advancement stage (p=0.0054).
|
25075030 |
2014 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we found that NgBR expression is associated with a poor prognosis of human hepatocellular carcinoma (HCC) patients.
|
26840457 |
2016 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Previously, we found that NgBR promotes the membrane translocation and activation of Ras in breast cancer cells and enhances the chemoresistance of hepatocellular carcinoma cells to 5-fluorouracil.
|
29331415 |
2018 |
|
Cardiomyopathy, Familial Idiopathic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We examined NgBR expression in 233 patients with invasive ductal breast carcinoma (IDC) and corresponding non-malignant breast tissues (NMBT) on mRNA (real-time polymerase chain reaction) and protein levels (immunohistochemistry; IHC and western-blot analysis).
|
25202063 |
2014 |
|
Hypertriglyceridemia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Deficiency of hepatic Nogo-B receptor (NgBR) expression activates liver X receptor α (LXRα) in an adenosine monophosphate-activated protein kinase α (AMPKα)-dependent manner, thereby inducing severe hepatic lipid accumulation and hypertriglyceridemia.
|
29217477 |
2018 |
|
Secondary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast, NgBR overexpression promoted EMT in and lung metastasis of NSCLC cells.
|
29331415 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
NUS1 overexpression on cell migration and invasion promoted the EMT process in vitro and in vivo.
|
31154456 |
2019 |
|
Peripheral Arterial Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Levels of NOGO-B and its receptor NUS1 were increased and ADAMTS-5 was decreased in patients with CAD+PAD.
|
29638194 |
2018 |
|
Coronary Artery Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Levels of NOGO-B and its receptor NUS1 were increased and ADAMTS-5 was decreased in patients with CAD+PAD.
|
29638194 |
2018 |
|
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Iaa
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Iaa
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Coding mutations in NUS1 contribute to Parkinson's disease.
|
30348779 |
2018 |
|
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Iaa
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|